Here's a quote from one of the articles:
How did so many smart people get it so wrong? Medicinal chemist Derek Lowe,
who works in drug development for a pharmaceutical firm, offered an explanation
in his "In the Pipeline" blog. "I worked on central nervous system drugs for
eight years, and I can confidently state that we know just slightly more than
jack" about how antidepressants work.
I don't doubt the fact that depression is real. Not for a second. But it is interesting to read how they came up with such a theory (you can't actually go into a human brain while the person is alive and take a count of serotonin levels). I also don't doubt that the drugs work for some people, but I do believe that drug companies turn vague theories into stories complete cartoon characters when the scientists themselves aren't sure how the drugs work. Storytelling helps to simplify things which in turn helps to sell more drugs.